第九週碩博專討演講(4/13)
2023.04.09
演講者：鍾仁傑 教授
國立台北科技大學 化學工程與生物科技系
題目：多功能奈米顆粒應用於癌症診斷治療與藥物制放
Multifunctional Nanoparticle for Cancer Theranostics and Drug Delivery
內容摘要：
Cancer is characterized by an uncontrolled division of cells and continues to be the leading cause of death. According to a recent survey, 1,735,350 new cancer patients and 609,640 cancer deaths are estimated to occur in 2018 in United States alone. Notably, nearly 2% decline in the cancer deaths has been observed based on data of the past decade. While it seems like a small percentage, the numbers are significant. This reduction is majorly due to the emergence of new methodologies to deal with cancer disease. Nanoparticles, in particular, have been extensively employed to target cancer. For instance, gold, iron oxide and silica nanoparticles have found applications in tumor imaging, drug delivery and photodynamic therapy, respectively. This is attributed to the nano size of these particles which makes it easier to be engulfed by the cells where the disease-specific treatment can be delivered. Further, processes such as Enhanced Permeability Retention (EPR) lead to accumulation of nano-particulate carriers, prolonging the circulation and making them an ideal choice of vehicle for cancer therapy. Magnetic hyperthermia therapy (MHT) is a highly promising therapeutic strategy for treating various cancers because of its remarkable effectiveness, low cost, non-invasiveness, minimized damage to normal tissues, and excellent tissue penetrability. Typically, magnetic nanoparticles (MNPs) are delivered to cancer cells to generate a considerable amount of heat upon exposure to an alternating magnetic field (AMF). In general, cancer cells are more sensitive to hyperthermia than normal cells and undergo apoptosis when exposed to elevated temperatures between 42-46 °C. In contrast, healthy cells can survive this temperature range. It has also been validated that magnetic hyperthermia at suitable temperatures increases the susceptibility of cancer cells to chemotherapy, radiation, and immunotherapy.
時間： 2023/04/13 (Thu) 3:10 PM
地點：成功校區三系館鋼構區(3F)共同教室 A1302演講廳
國立台北科技大學 化學工程與生物科技系
題目：多功能奈米顆粒應用於癌症診斷治療與藥物制放
Multifunctional Nanoparticle for Cancer Theranostics and Drug Delivery
內容摘要：
Cancer is characterized by an uncontrolled division of cells and continues to be the leading cause of death. According to a recent survey, 1,735,350 new cancer patients and 609,640 cancer deaths are estimated to occur in 2018 in United States alone. Notably, nearly 2% decline in the cancer deaths has been observed based on data of the past decade. While it seems like a small percentage, the numbers are significant. This reduction is majorly due to the emergence of new methodologies to deal with cancer disease. Nanoparticles, in particular, have been extensively employed to target cancer. For instance, gold, iron oxide and silica nanoparticles have found applications in tumor imaging, drug delivery and photodynamic therapy, respectively. This is attributed to the nano size of these particles which makes it easier to be engulfed by the cells where the disease-specific treatment can be delivered. Further, processes such as Enhanced Permeability Retention (EPR) lead to accumulation of nano-particulate carriers, prolonging the circulation and making them an ideal choice of vehicle for cancer therapy. Magnetic hyperthermia therapy (MHT) is a highly promising therapeutic strategy for treating various cancers because of its remarkable effectiveness, low cost, non-invasiveness, minimized damage to normal tissues, and excellent tissue penetrability. Typically, magnetic nanoparticles (MNPs) are delivered to cancer cells to generate a considerable amount of heat upon exposure to an alternating magnetic field (AMF). In general, cancer cells are more sensitive to hyperthermia than normal cells and undergo apoptosis when exposed to elevated temperatures between 42-46 °C. In contrast, healthy cells can survive this temperature range. It has also been validated that magnetic hyperthermia at suitable temperatures increases the susceptibility of cancer cells to chemotherapy, radiation, and immunotherapy.
時間： 2023/04/13 (Thu) 3:10 PM
地點：成功校區三系館鋼構區(3F)共同教室 A1302演講廳