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主旨 第十五週碩博專討演講公告(06/11)
公告日期 2020-06-05
公告內容

碩博專題演講公告

題  目: Applications of single-particle tracking in visualizing EGFR trafficking and assessing the metastatic potential of cancer cells

主講人: 劉彥良 博士 

現職: 中國醫藥大學 生物醫學研究所 助理教授

專長領域:科學傳播

內容摘要:

Whereas important discoveries made by single-particle tracking (SPT) have changed our view of the plasma membrane organization and motor protein dynamics, experimental studies of intracellular processes using SPT are rather scarce due to the lack of 3D tracking technique, trajectory analysis algorithm, and validation. Dr. Liu will present his work on the developments of a 3D tracking technique, a trajectory analysis algorithm, and, eventually, an SPT-based biophysical phenotyping assay named “Transmembrane Receptor Dynamics (TReD)” for assessing metastatic potentials of breast and prostate cancer cells. It’s the first time that the dynamics of epidermal growth factor receptor (EGFR) was used to differentiate metastatic cancer cell from less invasive ones. Most importantly, the TReD assay can be integrated with circulating tumor cell isolation microfluidic chip for a streamlined cancer diagnostic procedure. Thus, we believe that the SPT-based EGFR dynamics can serve as a new biophysical assay to probe the metastatic potential of cancer cells and to monitor their response to anti-cancer drug treatments.

時  間:民國 109 年 06 月 11 日 下午 3:10

地  點:成功大學數位學習平台

 

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最後修改時間 2020-06-04 14:56:54